Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1133
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Clobetasol Propionate (Cream)
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| dailymed-instance:dosage |
Apply a thin layer of Clobetasol Propionate Cream USP to the affected skin areas twice daily and rub in gently and completely. Clobetasol Propionate Cream USP is a super-high potency topical corticosteroid; therefore, treatment should be limited to 2 consecutive weeks, and amounts greater than 50 grams per week should not be used. As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Clobetasol Propionate Cream USP should not be used with occlusive dressings.
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| dailymed-instance:descripti... |
Clobetasol Propionate Cream USP contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity. Chemically, clobetasol propionate is (11��, 16��)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione, and it has the following structural formula: Clobetasol propionate has the molecular formula CHClFOand a molecular weight of 467. It is a white to cream-colored crystalline powder insoluble in water. Each gram of Clobetasol Propionate Cream USP, 0.05% contains 0.5 mg clobetasol propionate in a cream base of purified water, propylene glycol, cetyl alcohol, stearyl alcohol, glyceryl stearate/polyethylene glycol 100 stearate, glyceryl monostearate BP, and white wax, with chlorocresol as a preservative, and sodium citrate and citric acid for pH adjustment.
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| dailymed-instance:clinicalP... |
Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase Ainhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours has not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Studies performed with clobetasol propionate cream indicate that it is in the super-high range of potency as compared with other topical corticosteroids.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Clobetasol propionate cream is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Clobetasol Propionate Cream USP, 0.05% is supplied in 15 g, 30 g, 45 g, and 60 g tubes.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:chlorocresol,
dailymed-ingredient:citric_acid,
dailymed-ingredient:glyceryl_monostearate_BP,
dailymed-ingredient:glyceryl_stearate/polyethylene_glycol_100_stearate,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sodium_citrate,
dailymed-ingredient:stearyl_alcohol,
dailymed-ingredient:water,
dailymed-ingredient:white_wax
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| dailymed-instance:overdosag... |
Topically applied clobetasol propionate can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Clobetasol Propionate
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| dailymed-instance:fullName |
Clobetasol Propionate (Cream)
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| dailymed-instance:adverseRe... |
In controlled clinical trials, the most frequent adverse reactions reported for clobetasol propionate cream were burning and stinging sensation in 1% of treated patients. Less frequent adverse reactions were itching, skin atrophy, and cracking and fissuring of the skin. Cushing's syndrome has been reported in infants and adults as a result of prolonged use of topical clobetasol propionate formulations. The following additional local adverse reactions have been reported with topical corticosteroids, and they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids. These reactions are listed in an approximately decreasing order of occurrence: dryness, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, irritation, striae, and miliaria.
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| dailymed-instance:indicatio... |
Clobetasol propionate cream is a super-high potency corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 grams per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in children under 12 years of age is not recommended. As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Clobetasol Propionate
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