Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/106
| Subject | Predicate | Object | Context |
|---|---|---|---|
| dailymed-drugs:106 | rdf:type | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:106 | rdf:type | dailymed-instance:drugs | lld:dailymed |
| dailymed-drugs:106 | rdfs:label | Erythromycin (Ointment) | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:dosage | In the treatment of superficial ocular infections, erythromycin ophthalmic ointment approximately 1 cm in length should be applied directly to the infected eye(s) up to six times daily, depending on the severity of the infection. For prophylaxis of neonatal gonococcal or chlamydial ophthalmia, a ribbon of ointment approximately 1 cm in length should be instilled into each lower conjunctival sac. The ointment should not be flushed from the eye following instillation. A new tube should be used for each infant. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:descripti... | Erythromycin Ophthalmic Ointment USP belongs to the macrolide group of antibiotics. The sterile ophthalmic ointment flows freely over the conjunctiva. Erythromycin base, as crystals or powder, is slightly soluble in water, moderately soluble in ether, and readily soluble in alcohol or chloroform. Erythromycin is an antibiotic produced from a strain of Streptomyces erythraeus. It is basic and readily forms asalt when combined with an acid. It has the following structural formula: CHNO Mol. Wt. 733.94 Chemical Name: (3R���, 4S���, 5S���, 6R���, 7R���, 9R���, 11R���, 12R���, 13S���, 14R���)-4-[(2,6-Dideoxy-3-C-methyl-3-0-methyl-��-L-ribo-hexopyranosyl)oxy]-14-ethyl-7, 12, 13-trihydroxy-3, 5, 7, 9, 11, 13 hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-��-D-xylo-opyranosyl]oxy]oxacyclotetradecane-2, 10-dione Each Gram Contains: ACTIVE: Erythromycin, USP 5 mg (0.5%); INACTIVES: White Petrolatum, Mineral Oil. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:clinicalP... | Microbiology: Erythromycin inhibits protein synthesis without affecting nucleic acid synthesis. Erythromycin is usually active against the following organisms in vitro and in clinical infections: Streptococcus pyogenes (group A��-hemolytic), Alpha-hemolytic streptococci (viridans group); Staphylococcus aureus, including penicillinase-producing strains (methicillin-resistant staphylococci are uniformly resistant to erythromycin); Streptococcus pneumoniae; Mycoplasma pneumoniae (Eaton Agent, PPLO); Haemophilus influenzae (not all strains of this organism are susceptible at the erythromycin concentrations ordinarily achieved); Treponema pallidum; Corynebacterium diphtheriae; Neisseria gonorrhoeae; Chlamydia trachomatis. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:activeIng... | dailymed-ingredient:ERYTHRO... | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:contraind... | This drug is contraindicated in patients with a history of hypersensitivity to erythromycin. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:supply | Erythromycin Ophthalmic Ointment USP, 0.5% is available in the following sizes: 1/8 oz. (3.5 g) tamper-resistant tube���09234 DO NOT USE IF CAP AND NECKRING ARE NOT INTACT. 1 g tin container (in cartons of 50) DO NOT USE IF BOTTOM RIDGE OF TUBE CAP IS EXPOSED. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:genericDr... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:activeMoi... | dailymed-ingredient:ERYTHRO... | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:inactiveI... | dailymed-ingredient:mineral... | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:inactiveI... | dailymed-ingredient:white_p... | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:precautio... | General: The use of antimicrobial agents may be associated with the overgrowth of non-susceptible organisms including fungi; in such a case, antibiotic administration should be stopped and appropriate measures taken.<br/>Information for patients: Avoid contaminating the tip of container with material from the eye, fingers or other source.<br/>Carcinogenesis, mutagenesis, impairment of fertility: Avoid contaminating the tip of container with material from the eye, fingers or other source.<br/>Pregnancy:<br/>Pregnancy Category B: Reproduction studies have been performed in rats, mice, and rabbits using erythromycin and its various salts and esters, at doses that were several multiples of the usual human dose. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproductive studies are not always predictive of human response, the erythromycins should be used during pregnancy only if clearly needed.<br/>Nursing mothers: Caution should be exercised when erythromycin is administered to a nursing woman.<br/>Pediatric use: See Indications and Usage and Dosage and Administration. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:genericMe... | Erythromycin | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:fullName | Erythromycin (Ointment) | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:adverseRe... | The most frequently reported adverse reactions are minor ocular irritations, redness and hypersensitivity reactions. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:indicatio... | For the treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by organisms susceptible to erythromycin. For prophylaxis of ophthalmia neonatorum due to N. gonorrhoeae or C. trachomatis. The effectiveness of erythromycin in the prevention of ophthalmia caused by penicillinase-producing N. gonorrhoeae is not established. For infants born to mothers with clinically apparent gonorrhea, intravenous or intramuscular injections of aqueous crystalline penicillin G should be given; a single dose of 50,000 units for term infants or 20,000 units for infants of low birth weight. Topical prophylaxis alone is inadequate for these infants. | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:represent... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:routeOfAd... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:106 | dailymed-instance:name | Erythromycin | lld:dailymed |
| http://www4.wiwiss.fu-berli... | dailymed-instance:producesD... | dailymed-drugs:106 | lld:dailymed |