Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1058
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| rdf:type | |
| rdfs:label |
Potassium Chloride in Dextrose (Injection, Solution)
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| dailymed-instance:dosage |
As directed by a
physician. Dosage is dependent upon the age, weight and clinical
condition of the patient as well as laboratory determinations. Parenteral drug
products should be inspected visually for particulate matter and
discoloration prior to administration whenever solution and container
permit. Use of a final filter is recommended during administration of
all parenteral solutions, where possible. All injections in
VIAFLEX Plus plastic containers are intended for intravenous
administration using sterile equipment. Additives may be
incompatible. Complete information is not available. Those additives
known to be incompatible should not be used. Consult with pharmacist, if available. If, in the informed judgment of the physician, it is deemed
advisable to introduce additives, use aseptic technique. Mix thoroughly
when additives have been introduced. Do not store solutions containing
additives
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| dailymed-instance:descripti... |
Potassium Chloride
in 5% Dextrose Injection, USP is a sterile, nonpyrogenic solution for
fluid and electrolyte replenishment and caloric supply in a single dose
container for intravenous administration. It contains no antimicrobial
agents. Composition, osmolarity, pH, ionic concentration and caloric
content are shown in Table 1. This VIAFLEX Plus
plastic container is fabricated from a specially formulated polyvinyl
chloride (PL 146 Plastic). VIAFLEX Plus on the container indicates the
presence of a drug additive in a drug vehicle. The VIAFLEX Plus plastic
container system utilizes the same container as the VIAFLEX plastic
container system. The amount of water that can permeate from inside the
container into the overwrap is insufficient to affect the solution
significantly. Solutions in contact with the plastic container can leach
out certain of its chemical components in very small amounts within the
expiration period, e.g., di-2- ethylhexyl phthalate (DEHP), up to 5
parts per million. However, the safety of the plastic has been confirmed
in tests in animals according to USP biological tests for plastic
containersas well as by tissue culture toxicity studies.
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| dailymed-instance:clinicalP... |
Potassium Chloride in 5% Dextrose Injection, USP is a source of water, electrolytes and
calories. It is capable of inducing diuresis depending on the clinical
condition of the patient.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Solutions
containing dextrose may be contraindicated in patients with known
allergy to corn or corn products
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| dailymed-instance:supply |
Potassium Chloride in 5% Dextrose Injection, USP in VIAFLEX Plus plastic container is
available as follows Exposure of
pharmaceutical products to heat should be minimized. Avoid excessive heat. It is recommended the product be stored at room temperature
(25��C); brief exposure up to 40��C does not adversely affect the
product.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:precautio... |
Clinical evaluation
and periodic laboratory determinations are necessary to monitor changes
in fluid balance, electrolyte concentrations, and acid base balance
during prolonged parenteral therapy or whenever the condition of the
patient warrants such evaluation. Potassium Chloride in 5% Dextrose Injection, USP should be used with caution in patients
with overt or subclinical diabetes mellitus.<br/>Pregnancy:<br/>Teratogenic
Effects:<br/>Pediatric Use: Safety and
effectiveness of Potassium Chloride in 5% Dextrose Injection in
pediatric patients have not been established by adequate and
well-controlled studies. However, the use of potassium chloride
injection in pediatric patients to treat potassium deficiency
states when oral replacement therapy is not feasible is
referenced in the medical literature. Dextrose is
safe and effective for the stated indications in pediatric
patients (see INDICATIONS
AND USAGE). As reported in the literature, the
dosage selection and constant infusion rate of intravenous
dextrose must be selected with caution in pediatric patients,
particularly neonates and low birth weight infants, because of the increased risk of hyperglycemia/hypoglycemia. Frequent
monitoring of serum glucose concentrations is required when
dextrose is prescribed to pediatric patients, particularly
neonates and low birth weight infants. For
patients receiving potassium supplement at greater than
maintenance rates, frequent monitoring of serum potassium levels
and serial EKGs are recommended.<br/>Geriatric Use: Clinical
studies of Potassium Chloride in 5% Dextrose Injection, USP did
not include sufficient numbers of subjects aged 65 and over to
determine whether they respond differently from younger
subjects. Other reported clinical experience has not identified
differences in responses between the elderly and younger
patients. In general, dose selection for an elderly patient
should be cautious, usually starting at the low end of the
dosing range, reflecting the greater frequency of decreased
hepatic, renal, or cardiac function, and of concomitant disease
or other drug therapy. This drug
is known to be substantially excreted by the kidney, and the
risk of toxic reactions to this drug may be greater in patients
with impaired renal function. Because elderly patients are more
likely to have decreased renal function, care should be taken in
dose selection, and it may be useful to monitor renal function.<br/>Nursing Mothers: It is not
known whether this drug is excreted in human milk. Because many
drugs are excreted in human milk, caution should be exercised
when Potassium Chloride in 5% Dextrose Injection, USP is
administered to a nursing mother. Do not
administer unless solution is clear and seal is
intact.
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| dailymed-instance:genericMe... |
potassium chloride and dextrose
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| dailymed-instance:fullName |
Potassium Chloride in Dextrose (Injection, Solution)
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| dailymed-instance:adverseRe... |
Reactions which may
occur because of the solution or the technique of administration include
febrile response, infection at the site of injection, venous thrombosis
or phlebitis extending from the site of injection, extravasation, and
hypervolemia. If an adverse reaction does occur, discontinue the infusion, evaluate the patient,
institute appropriate therapeutic countermeasures, and save the
remainder of the fluid for examination if deemed necessary.
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| dailymed-instance:warning |
Potassium Chloride
in 5% Dextrose Injection, USP should be used with great care, if at all,
in patients with hyperkalemia, severe renal failure, and in conditions
in which potassium retention is present. Injections
containing carbohydrates with low electrolyte concentration should not
be administered simultaneously with blood through the same
administration set because of the possibility of pseudoagglutination or
hemolysis. The bag label for these injections bears the statement: Do
not administer simultaneously with blood. The intravenous
administration of Potassium Chloride in 5% Dextrose Injection, USP can
cause fluid and/or solute overloading resulting in dilution of serum
electrolyte concentrations, overhydration, congested states, or
pulmonary edema. The risk of dilutional states is inversely proportional
to the electrolyte concentrations of the injection. The risk of solute
overload causing congested states with peripheral and pulmonary edema is
directly proportional to the electrolyte concentrations of the
injection. In patients with
diminished renal function, administration of Potassium Chloride in 5%
Dextrose Injection, USP may result in potassium retention. In very low birth
weight infants, excessive or rapid administration of dextrose injection
may result in increased serum osmolality and possible intracerebral
hemorrhage. Potassium salts
should never be administered by IV push
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| dailymed-instance:indicatio... |
Potassium Chloride
in 5% Dextrose Injection, USP is indicated as a source of water,
electrolytes, and calories.
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| dailymed-instance:name |
Potassium Chloride in Dextrose
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