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dailymed-drugs:1020rdfs:labelPrednisoLONE (Solution)lld:dailymed
dailymed-drugs:1020dailymed-instance:dosageDosage of PrednisoLONE Syrup (PrednisoLONE Oral Solution USP) should be individualized according to the severity of the disease and the response of the patient. For infants and children, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight. Hormone therapy is an adjunct to and not a replacement for conventional therapy. Dosage should be decreased or discontinued gradually when the drug has been administered for more than a few days. The severity, prognosis, expected duration of the disease, and the reaction of the patient to medication are primary factors in determining dosage. If a period of spontaneous remission occurs in a chronic condition, treatment should be discontinued. Blood pressure, body weight, routine laboratory studies, including two-hour postprandial blood glucose and serum potassium, and a chest X-ray should be obtained at regular intervals during prolonged therapy. Upper GI X-rays are desirable in patients with known or suspected peptic ulcer disease. The initial dosage of PrednisoLONE Syrup (PrednisoLONE Oral Solution USP) may vary from 5 mg to 60 mg per day depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time there is a lack of satisfactory clinical response, PrednisoLONE Syrup (PrednisoLONE Oral Solution USP) should be discontinued and the patient transferred to other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment. In this latter situation it may be necessary to increase the dosage of PrednisoLONE Syrup (PrednisoLONE Oral Solution USP) for a period of time consistent with the patient's condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.lld:dailymed
dailymed-drugs:1020dailymed-instance:clinicalP...Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs such as prednisolone are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. Glucocorticoids such as prednisolone cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.lld:dailymed
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dailymed-drugs:1020dailymed-instance:supplyPrednisoLONE Syrup (PrednisoLONE Oral Solution USP) is a berry-flavored, red liquid containing 15 mg of prednisolone in each 5 mL (teaspoonful) and is supplied in 8 fl oz bottles (NDC 0121- 0687-08), 16 fl oz bottles (NDC 0121- 0687-16) and 5 mL unit dose cups packaged in trays of 10 (NDC 0121-0687-05). Pharmacist: Dispense with a suitable calibrated measuring device to assure proper measuring of dose. Dispense in tight, light-resistant and child-resistant containers as defined in the USP/NF. Dose/Volume Chart 15 mg prednisolone = 1 teaspoon 10 mg prednisolone = 2/3 teaspoon 7.5 mg prednisolone = 1/2 teaspoon 5 mg prednisolone = 1/3 teaspoon Store at controlled room temperature, 20��-25��C (68��-77��F). [See USP] DO NOT REFRIGERATE. R11/06 PharmaceuticalAssociates, Inc.Greenville, SC 29605lld:dailymed
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dailymed-drugs:1020dailymed-instance:fullNamePrednisoLONE (Solution)lld:dailymed
dailymed-drugs:1020dailymed-instance:adverseRe...Fluid and Electrolyte DisturbancesSodium retentionFluid retentionCongestive heart failure in susceptible patientsPotassium lossHypokalemic alkalosisHypertension MusculoskeletalMuscle weaknessSteroid myopathyLoss of muscle massOsteoporosisVertebral compression fracturesAseptic necrosis of femoral and humeral headsPathologic fracture of long bones GastrointestinalPeptic ulcer with possible perforation and hemorrhagePancreatitisAbdominal distentionUlcerative esophagitis DermatologicImpaired wound healingThin fragile skinPetechiae and ecchymosesFacial erythemaIncreased sweatingMay suppress reactions to skin tests NeurologicalConvulsionsIncreased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatmentVertigoHeadache EndocrineMenstrual irregularitiesDevelopment of Cushingoid stateSuppression of growth in pediatric patientsSecondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illnessDecreased carbohydrate toleranceManifestations of latent diabetes mellitusIncreased requirements for insulin or oral hypoglycemic agents in diabetics OphthalmicPosterior subcapsular cataractsIncreased intraocular pressureGlaucomaExophthalmos MetabolicNegative nitrogen balance due to protein catabolismlld:dailymed
dailymed-drugs:1020dailymed-instance:indicatio...PrednisoLONE Syrup (PrednisoLONE Oral Solution USP) is indicated in the following conditions: In addition to the above indications, PrednisoLONE Syrup (PrednisoLONE Oral Solution USP) is indicated for systemic dermatomyositis (polymyositis).lld:dailymed
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