Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/102
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Potassium Chloride and Dextrose (Injection, Solution)
|
| dailymed-instance:dosage |
As directed by a
physician. Dosage is dependent upon the age, weight and clinical
condition of the patient as well as laboratory determinations. Parenteral drug
products should be inspected visually for particulate matter and
discoloration prior to administration whenever solution and container
permit. Use of a final filter is recommended during administration of
all parenteral solutions, where possible. All injections in
VIAFLEX Plus plastic containers are intended for intravenous
administration using sterile equipment. Additives may be
incompatible. Complete information is not available. Those additives
known to be incompatible should not be used. Consult with pharmacist, if
available. If, in the informed judgment of the physician, it is deemed
advisable to introduce additives, use aseptic technique. Mix thoroughly
when additives have been introduced. Do not store solutions containing
additives.
|
| dailymed-instance:descripti... |
Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP is a sterile,
nonpyrogenic solution for fluid and electrolyte replenishment and
caloric supply in a single dose container for intravenous
administration. It contains no antimicrobial agents. Composition,
osmolarity, pH, ionic concentration and caloric content are shown below: The VIAFLEX Plus
plastic container is fabricated from a specially formulated polyvinyl
chloride (PL 146 Plastic). VIAFLEX Plus on the container indicates the
presence of a drug additive in a drug vehicle. The VIAFLEX Plus plastic
container system utilizes the same container as the VIAFLEX plastic
container system. The amount of water that can permeate from inside the
container into the overwrap is insufficient to affect the solution
significantly. Solutions in contact with the plastic container can leach
out certain of its chemical components in very small amounts within the
expiration period, e.g., di-2- ethylhexyl phthalate (DEHP), up to 5
parts per million. However, the safety of the plastic has been confirmed
in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.
|
| dailymed-instance:clinicalP... |
Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP have value as a
source of water, electrolytes, and calories. It is capable of inducing
diuresis depending on the clinical condition of the patient. Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP produce a metabolic
alkalinizing effect. Lactate ions are metabolized ultimately to carbon
dioxide and water, which requires the consumption of hydrogen
cations.
|
| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Solutions
containing dextrose may be contraindicated in patients with known
allergy to corn or corn products.
|
| dailymed-instance:supply |
Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP in VIAFLEX Plus
plastic containers is available as shown below: Exposure of
pharmaceutical products to heat should be minimized. Avoid excessive
heat. It is recommended the product be stored at room temperature
(25��C); brief exposure up to 40��C does not adversely affect the product.
|
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:precautio... |
Clinical evaluation
and periodic laboratory determinations are necessary to monitor changes
in fluid balance, electrolyte concentrations, and acid base balance
during prolonged parenteral therapy or whenever the condition of the
patient warrants such evaluation. Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP should be used with
caution. Excess administration may result in metabolic alkalosis. Caution must be exercised in the administration of Potassium Chloride in Lactated
Ringer's and 5% Dextrose Injection, USP to patients receiving
corticosteroids or corticotropin. Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP should be used with
caution in patients with overt or subclinical diabetes
mellitus.<br/>Pregnancy:<br/>Teratogenic
Effects:<br/>Pediatric Use: Safety and
effectiveness of Potassium Chloride in Lactated Ringer's and 5% Dextrose Injection, USP in pediatric patients have not been
established by adequate and well-controlled studies. However,
the use of potassium chloride injection in pediatric patients to
treat potassium deficiency states when oral replacement therapy
is not feasible is referenced in the medical literature. Dextrose is
safe and effective for the stated indications in pediatric
patients (see INDICATIONS
AND USAGE). As reported in the literature, the
dosage selection and constant infusion rate of intravenous
dextrose must be selected with caution in pediatric patients,
particularly neonates and low birth weight infants, because of
the increased risk of hyperglycemia/hypoglycemia. Frequent
monitoring of serum glucose concentrations is required when
dextrose is prescribed to pediatric patients, particularly
neonates and low birth weight infants.<br/>Geriatric Use: Clinical
studies of Potassium Chloride in Lactated Ringer's and 5%
Dextrose Injection, USP did not include sufficient numbers of
subjects aged 65 and over to determine whether they respond
differently from younger subjects. Other reported clinical
experience has not identified differences in responses between
the elderly and younger patients. In general, dose selection for
an elderly patient should be cautious, usually starting at the
low end of the dosing range, reflecting the greater frequency of
decreased hepatic, renal, or cardiac function, and ofconcomitant disease or drug therapy. For
patients receiving potassium supplement at greater than
maintenance rates, frequent monitoring of serum potassium levels
and serial EKGs are recommended. This drug
is known to be substantially excreted by the kidney, and the
risk of toxic reactions to this drug may be greater in patients
with impaired renal function. Because elderly patients are more
likely to have decreased renal function, care should be taken in
dose selection, and it may be useful to monitor renal function.<br/>Carcinogenesis,
Mutagenesis, Impairment of Fertility: Studies
with Potassium Chloride in Lactated Ringer's and 5% Dextrose
Injection, USP have not been performed to evaluate carcinogenic
potential, mutagenic potential or effects on
fertility.<br/>Nursing Mothers: It is not
known whether this drug is excreted in human milk. Because many
drugs are excreted in human milk, caution should be exercised
when Potassium Chloride in Lactated Ringer's and 5% Dextrose
Injection, USP is administered to a nursing mother. Do not
administer unless solution is clear and seal is
intact.
|
| dailymed-instance:genericMe... |
Sodium chloride, Sodium lactate, Potassium Chloride, Calcium chloride and Dextrose monohydrate
|
| dailymed-instance:fullName |
Potassium Chloride and Dextrose (Injection, Solution)
|
| dailymed-instance:adverseRe... |
Reactions which may
occur because of the solution or the technique of administration include
febrile response, infection at the site of injection, venous thrombosis
or phlebitis extending from the site of injection, extravasation, and
hypervolemia. If an adverse
reaction does occur, discontinue the infusion, evaluate the patient,
institute appropriate therapeutic countermeasures, and save the
remainder of the fluid for examination if deemed necessary.
|
| dailymed-instance:warning |
Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP should be used with
great care, if at all, in patients with congestive heart failure, severe
renal insufficiency, and in clinical states in which there exists edema with sodium retention. Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP should be used with
great care, if at all, in patients with hyperkalemia, severe renal
failure, and in conditions in which potassium retention is present. Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP should be used with
great care in patients with metabolic or respiratory alkalosis. The
administration of lactate ions should be done with great care in those
conditions in which there is an increased level or an impaired
utilization of these ions, such as severe hepatic insufficiency. Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP should not be
administered simultaneously with blood through the same administration
set because of the likelihood of coagulation. The intravenous
administration of Potassium Chloride in Lactated Ringer's and 5%
Dextrose Injection, USP can cause fluid and/or solute overloading
resulting in dilution of serum electrolyte concentrations,
overhydration, congested states, or pulmonary edema. The risk of
dilutional states is inversely proportional to the electrolyte
concentrations of the injection. The risk of solute overload causing
congested states with peripheral and pulmonary edema is directly
proportional tothe electrolyte concentrations of the injection. In patients with
diminished renal function, administration of Potassium Chloride in
Lactated Ringer's and 5% Dextrose Injection, USP may result in sodium or
potassium retention. Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP is not for use in
the treatment of lactic acidosis. In very low birth
weight infants, excessive or rapid administration of dextrose injection
may result in increased serum osmolality and possible intracerebral
hemorrhage. Potassium salts
should never be administered by IV push.
|
| dailymed-instance:indicatio... |
Potassium Chloride
in Lactated Ringer's and 5% Dextrose Injection, USP are indicated as a
source of water, electrolytes, and calories or as alkalinizing
agents.
|
| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Potassium Chloride and Dextrose
|