| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Vacuolar protein sorting-associated protein 4
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| http://www.biopax.org/relea... |
VPS4_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
DOA4-independent degradation protein 6,
Protein END13,
Vacuolar protein-targeting protein 10
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| http://www.biopax.org/relea... |
FUNCTION: Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. SUBUNIT: Monomer or homodimer (in nucleotide-free form). Decamer, dodecamer or tetradecamer of two stacked respective homooligomeric rings (when bound to ATP); the dodecameric form seems to be predominant. Interacts with VPS20. Interacts with VTA1; the interaction requires the dimeric structure of VTA1; 6 homodimers of VTA1 appear to associate with the dodecameric VSP4 complex. Interacts with DID2. Interacts with DID4. Interacts with IST1; IST1 competes with VTA1 for binding with VPS4. SUBCELLULAR LOCATION: Endosome membrane; Peripheral membrane protein (By similarity). MISCELLANEOUS: Present with 5350 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the AAA ATPase family. SIMILARITY: Contains 1 MIT domain. GENE SYNONYMS: CSC1 DID6 END13 GRD13 VPL4 VPT10. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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