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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cold-inducible RNA-binding protein
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| http://www.biopax.org/relea... |
CIRBP_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
A18 hnRNP,
Glycine-rich RNA-binding protein CIRP
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| http://www.biopax.org/relea... |
FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. SUBUNIT: Interacts with EIF4G1. Associates with ribosomes. SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). TISSUE SPECIFICITY: Ubiquitous. INDUCTION: By cold stress in response to DNA damage induced by UV irradiation or UV mimetic agents. Up-regulated by hypoxia. DOMAIN: Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity). PTM: Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity). PTM: Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. GENE SYNONYMS: A18HNRNP CIRP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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