| Predicate | Object |
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Calcium and integrin-binding protein 1
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| http://www.biopax.org/relea... |
CIB1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CIB,
CIBP,
Calcium- and integrin-binding protein,
Calmyrin,
DNA-PKcs-interacting protein,
KIP,
Kinase-interacting protein,
SIP2-28,
SNK-interacting protein 2-28
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| http://www.biopax.org/relea... |
FUNCTION: May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. SUBUNIT: Monomer. Interacts with the heterodimeric integrin alpha- IIb/beta3. Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK. Interacts with PSEN2. Interacts with MYO1C (By similarity). Interacts (via C-terminus) with F8. Interacts with NBR1 (via C- terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6. Interacts with BCL2. Interacts with TAS1R2 (via C- terminus); this interaction is independent of the myristoylation state of CIB1. Interacts with ITPR3; in a calcium dependent manner. Interacts with PTK2. Interacts with MAP3K5; inhibiting MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Cytoplasm. Nucleus. Cell projection, filopodium. Apical cell membrane. Note=Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 2 EF-hand domains. GENE SYNONYMS: CIB KIP PRKDCIP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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