| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
OTU domain-containing protein 7B
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| http://www.biopax.org/relea... |
OTU7B_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.19.12,
Cellular zinc finger anti-NF-kappa-B protein,
Zinc finger A20 domain-containing protein 1,
Zinc finger protein Cezanne
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| http://www.biopax.org/relea... |
FUNCTION: Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B. CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SUBUNIT: Interacts with TRAF6. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells. SIMILARITY: Belongs to the peptidase C64 family. SIMILARITY: Contains 1 A20-type zinc finger. SIMILARITY: Contains 1 OTU domain. SEQUENCE CAUTION: Sequence=CAB97494.1; Type=Erroneous initiation; GENE SYNONYMS: ZA20D1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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