| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Protein ORM2
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| http://www.biopax.org/relea... |
ORM2_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
FUNCTION: Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity. SUBUNIT: Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. PTM: Phosphorylated in case of disruption of sphingolipid synthesis. Phosphorylation regulates inhibitory activity of serine palmitoyltransferases (LCB1 and LCB2). MISCELLANEOUS: Present with 5240 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the ORM family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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