Linked Life Data

CPATH-90707

Source:http://cbio.mskcc.org/cpath#CPATH-90707

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-90707http://www.biopax.org/relea...Protein SLG1lld:biogrid
cpath:CPATH-90707http://www.biopax.org/relea...SLG1_YEASTlld:biogrid
cpath:CPATH-90707http://www.biopax.org/relea...cpath:CPATH-LOCAL-373372lld:biogrid
cpath:CPATH-90707http://www.biopax.org/relea...Synthetic lethal with GAP protein 1lld:biogrid
cpath:CPATH-90707http://www.biopax.org/relea...Cell wall integrity and stress response component 1lld:biogrid
cpath:CPATH-90707http://www.biopax.org/relea...FUNCTION: Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. PTM: Glycosylated. Phosphorylated. Phosphorylation serves a negative regulatory role. MISCELLANEOUS: Present with 664 molecules/cell in log phase SD medium. MISCELLANEOUS: Lack of SLG1 leads to a significant defect of 1,3- beta-glucan synthesis and confers sensitivity to caffeine, SDS, Calcofluor and alkaline pH stress. Deletion of residues 21-256 results in non-functional protein, removal of residues 21-110 yields a protein still able to confer some tolerance to alkaline stress, and deletion of residues 116-256 has no effect on the function. SIMILARITY: Contains 1 WSC domain. GENE SYNONYMS: WSC1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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cpath:CPATH-90707skos:closeMatchentrez-gene:854170lld:mappings
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cpath:CPATH-LOCAL-9175543http://www.biopax.org/relea...cpath:CPATH-90707lld:biogrid
cpath:CPATH-LOCAL-9408043http://www.biopax.org/relea...cpath:CPATH-90707lld:biogrid