| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-364669,
cpath:CPATH-LOCAL-364670,
cpath:CPATH-LOCAL-364671,
cpath:CPATH-LOCAL-364672,
cpath:CPATH-LOCAL-364673,
cpath:CPATH-LOCAL-364674,
cpath:CPATH-LOCAL-364675,
cpath:CPATH-LOCAL-364676,
cpath:CPATH-LOCAL-364677,
cpath:CPATH-LOCAL-364678,
cpath:CPATH-LOCAL-364679,
cpath:CPATH-LOCAL-364680,
cpath:CPATH-LOCAL-364681,
cpath:CPATH-LOCAL-364682,
cpath:CPATH-LOCAL-364683,
cpath:CPATH-LOCAL-364684,
cpath:CPATH-LOCAL-364685,
cpath:CPATH-LOCAL-368647
|
| http://www.biopax.org/relea... |
U1 small nuclear ribonucleoprotein 70 kDa
|
| http://www.biopax.org/relea... |
RU17_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
U1 snRNP 70 kDa,
U1-70K,
snRNP70
|
| http://www.biopax.org/relea... |
FUNCTION: Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA. SUBUNIT: Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P08621-1; Sequence=Displayed; Name=2; IsoId=P08621-2; Sequence=VSP_005850; Name=3; IsoId=P08621-3; Sequence=VSP_005848, VSP_005849; Name=4; IsoId=P08621-4; Sequence=VSP_005847; PTM: The N-terminus is blocked. PTM: Extensively phosphorylated on serine residues in the C- terminal region. MISCELLANEOUS: Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SEQUENCE CAUTION: Sequence=CAA28352.1; Type=Erroneous initiation; Sequence=CAA29964.1; Type=Erroneous initiation; Sequence=CAA29966.1; Type=Erroneous initiation; GENE SYNONYMS: RNPU1Z RPU1 SNRP70 U1AP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |