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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
B-cell antigen receptor complex-associated protein beta chain
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| http://www.biopax.org/relea... |
CD79B_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
B-cell-specific glycoprotein B29,
CD79b,
Ig-beta,
Immunoglobulin-associated B29 protein
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| http://www.biopax.org/relea... |
FUNCTION: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen- specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P40259-1; Sequence=Displayed; Name=Short; IsoId=P40259-2; Sequence=VSP_002477; TISSUE SPECIFICITY: B-cells. PTM: Phosphorylated on tyrosine upon B-cell activation. DISEASE: Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SIMILARITY: Contains 1 ITAM domain. WEB RESOURCE: Name=CD79Bbase; Note=CD79B mutation db; URL="http://bioinf.uta.fi/CD79Bbase/"; GENE SYNONYMS: B29 IGB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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