| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
C-C motif chemokine 3
|
| http://www.biopax.org/relea... |
CCL3_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
G0/G1 switch regulatory protein 19-1,
LD78-alpha(4-69),
MIP-1-alpha,
MIP-1-alpha(4-69),
Macrophage inflammatory protein 1-alpha,
PAT 464.1,
SIS-beta,
Small-inducible cytokine A3,
Tonsillar lymphocyte LD78 alpha protein
|
| http://www.biopax.org/relea... |
FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). SUBUNIT: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). SUBCELLULAR LOCATION: Secreted. INDUCTION: By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)). PTM: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T- cells. SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. WEB RESOURCE: Name=Wikipedia; Note=Macrophage inflammatory protein entry; URL="http://en.wikipedia.org/wiki/Macrophage_Inflammatory_Protein"; GENE SYNONYMS: G0S19-1 MIP1A SCYA3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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