Linked Life Data

CPATH-81903

Source:http://cbio.mskcc.org/cpath#CPATH-81903

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-81903http://www.biopax.org/relea...Central kinetochore subunit CTF3lld:biogrid
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cpath:CPATH-81903http://www.biopax.org/relea...Chromosome loss protein 3lld:biogrid
cpath:CPATH-81903http://www.biopax.org/relea...Chromosome transmission fidelity protein 3lld:biogrid
cpath:CPATH-81903http://www.biopax.org/relea...FUNCTION: Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle- microtubule attachments and proper chromosome segregation. SUBUNIT: Heterotrimer. CTF3, MCM16 and MCM22 form the CTF3 kinetochore subcomplex. The CTF3 subcomplex is part of a larger central kinetochore CTF19 complex, which is composed of at least AME1, CHL4, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, NKP1, NKP2 and OKP1. Interacts with CHL4 and CTF19. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. MISCELLANEOUS: Present with 319 molecules/cell in log phase SD medium. GENE SYNONYMS: CHL3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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