| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Calcium-binding and coiled-coil domain-containing protein 2
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| http://www.biopax.org/relea... |
CACO2_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Antigen nuclear dot 52 kDa protein,
Nuclear domain 10 protein 52,
Nuclear domain 10 protein NDP52,
Nuclear dot protein 52
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| http://www.biopax.org/relea... |
FUNCTION: May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion (By similarity). SUBUNIT: Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Golgi apparatus. Cytoplasm, cytoskeleton. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot- associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. TISSUE SPECIFICITY: Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. MISCELLANEOUS: According to PubMed:7540613, HSV-1 infection removes CALCOCO2 from the nucleus, however, it remains faintly in areas shown to be domains, containing splicing components. Treatment with IFNB1/IFN-beta and IFNG/IFN-gamma show an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm. According to PubMed:9230084, IFNG/IFN-gamma increases gene expression only slightly and IFNB does not increase expression. GENE SYNONYMS: NDP52. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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