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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Histone acetyltransferase KAT5
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| http://www.biopax.org/relea... |
KAT5_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.3.1.48,
60 kDa Tat-interactive protein,
Histone acetyltransferase HTATIP,
Lysine acetyltransferase 5,
Tip60
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| http://www.biopax.org/relea... |
FUNCTION: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM (By similarity). CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. SUBUNIT: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (By similarity). HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4 (By similarity). The NuA4 complex interacts with MYC (By similarity). Interacts with ATM (By similarity). Interacts with PHF17 (By similarity). Interacts with PLA2G4A/CPLA2, EDNRA and HDAC7 (By similarity). Interacts with the cytoplasmic tail of APP and APBB1/FE65 (By similarity). Interacts with TRIM24 and TRIM68 (By similarity). Forms a complex with SENP6 and UBE2I in response to UV irradiation (By similarity). SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm, perinuclear region (By similarity). Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8CHK4-1; Sequence=Displayed; Name=2; IsoId=Q8CHK4-2; Sequence=VSP_009107; Name=3; IsoId=Q8CHK4-3; Sequence=VSP_009106; Name=4; IsoId=Q8CHK4-4; Sequence=VSP_009105; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in testis, heart, brain, kidney and liver. Weakly expressed in lung. PTM: Sumoylated by UBE2I at Lys-430 and Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies (By similarity). PTM: Phosphorylated on Ser-86 and Ser-90; enhanced during G2/M phase. Phosphorylated form has a higher activity (By similarity). PTM: Ubiquitinated by MDM2, leading to its proteasome-dependent degradation (By similarity). SIMILARITY: Belongs to the MYST (SAS/MOZ) family. SIMILARITY: Contains 1 C2HC-type zinc finger. GENE SYNONYMS: Htatip Tip60. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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