| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cyclin-L1
|
| http://www.biopax.org/relea... |
CCNL1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cyclin-L
|
| http://www.biopax.org/relea... |
FUNCTION: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. SUBUNIT: Interacts with POLR2A via its hyperphosphorylated C- terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK11B, CDK12, CDK13 and SFRS2. SUBCELLULAR LOCATION: Nucleus speckle (By similarity). Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Comment=Ccnl1 is an immediate-early gene with independently regulated isoforms; Name=1; Synonyms=Cyclin L alpha; IsoId=Q9UK58-1; Sequence=Displayed; Name=2; Synonyms=Cyclin L beta; IsoId=Q9UK58-4; Sequence=VSP_016122, VSP_016123; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; Synonyms=Cyclin L gamma; IsoId=Q9UK58-5; Sequence=VSP_016120, VSP_016121; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; TISSUE SPECIFICITY: Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). DOMAIN: Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions. MISCELLANEOUS: CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC. SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily. SEQUENCE CAUTION: Sequence=AAF64257.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAQ89026.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |