| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Caspase recruitment domain-containing protein 11
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| http://www.biopax.org/relea... |
CAR11_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CARD-containing MAGUK protein 1,
Carma 1
|
| http://www.biopax.org/relea... |
FUNCTION: Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. SUBUNIT: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail). SUBCELLULAR LOCATION: Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. TISSUE SPECIFICITY: Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells. PTM: Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCBB leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling (By similarity). SIMILARITY: Contains 1 CARD domain. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 1 PDZ (DHR) domain. CAUTION: Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART. SEQUENCE CAUTION: Sequence=AAG53402.1; Type=Erroneous initiation; Sequence=AAI11720.2; Type=Erroneous initiation; Sequence=AAQ96893.1; Type=Erroneous gene model prediction; Sequence=EAL23962.1; Type=Erroneous gene model prediction; GENE SYNONYMS: CARMA1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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