| Predicate | Object |
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Ubiquitin carboxyl-terminal hydrolase 10
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| http://www.biopax.org/relea... |
UBP10_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.19.12,
Deubiquitinating enzyme 10,
Ubiquitin thiolesterase 10,
Ubiquitin-specific-processing protease 10
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| http://www.biopax.org/relea... |
FUNCTION: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). SUBUNIT: Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14694-1; Sequence=Displayed; Name=2; IsoId=Q14694-2; Sequence=VSP_038869; Name=3; IsoId=Q14694-3; Sequence=VSP_038868; Note=No experimental confirmation available; TISSUE SPECIFICITY: Widely expressed. INDUCTION: Following DNA damage. Down-regulated in renal cell carcinomas. PTM: Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus. SIMILARITY: Belongs to the peptidase C19 family. USP10 subfamily. SEQUENCE CAUTION: Sequence=CAD97644.1; Type=Erroneous initiation; GENE SYNONYMS: KIAA0190. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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