| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Nuclear receptor coactivator 2
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| http://www.biopax.org/relea... |
NCOA2_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
GRIP-1,
Glucocorticoid receptor-interacting protein 1,
NCoA-2,
Transcriptional intermediary factor 2
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| http://www.biopax.org/relea... |
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. SUBUNIT: Interacts with NR3C1. Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, RARA and RXRA (By similarity). Interacts with HIF1A, NCOA1, APEX, NR3C2, and CARM1. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (By similarity). DOMAIN: The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding (By similarity). DOMAIN: Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator family. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. SIMILARITY: Contains 1 PAS (PER-ARNT-SIM) domain. SEQUENCE CAUTION: Sequence=AAB61575.1; Type=Frameshift; Positions=251, 256, 302, 321, 959, 964, 983; GENE SYNONYMS: Grip1 Tif2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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