| Predicate | Object |
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
von Willebrand factor
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| http://www.biopax.org/relea... |
VWF_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
vWF,
von Willebrand antigen 2,
von Willebrand antigen II
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| http://www.biopax.org/relea... |
FUNCTION: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. SUBUNIT: Multimeric. Interacts with F8. SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules. TISSUE SPECIFICITY: Plasma. DOMAIN: The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds. PTM: N- and O-glycosylated. DISEASE: Defects in VWF are the cause of von Willebrand disease type 1 (VWD1) [MIM:193400]. A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. DISEASE: Defects in VWF are the cause of von Willebrand disease type 2 (VWD2) [MIM:613554]. A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. DISEASE: Defects in VWF are the cause of von Willebrand disease type 3 (VWD3) [MIM:277480]. A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses. SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. SIMILARITY: Contains 4 TIL (trypsin inhibitory-like) domains. SIMILARITY: Contains 3 VWFA domains. SIMILARITY: Contains 3 VWFC domains. SIMILARITY: Contains 4 VWFD domains. SEQUENCE CAUTION: Sequence=AAB59512.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; WEB RESOURCE: Name=vWF; Note=von Willebrand factor (vWF) mutation db; URL="http://www.vwf.group.shef.ac.uk/"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/VWF"; WEB RESOURCE: Name=Wikipedia; Note=Von Willebrand factor entry; URL="http://en.wikipedia.org/wiki/Von_Willebrand_factor"; GENE SYNONYMS: F8VWF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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