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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Protein VAC14 homolog
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| http://www.biopax.org/relea... |
VAC14_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Tax1-binding protein 2
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| http://www.biopax.org/relea... |
FUNCTION: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. SUBUNIT: Forms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. Interacts with NOS1. Interacts with HTLV-1 Tax. SUBCELLULAR LOCATION: Endosome membrane. Microsome membrane (By similarity). Note=Mainly associated with membranes of the late endocytic pathway. TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The C-terminal domain (residues 523-782) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex. SIMILARITY: Belongs to the VAC14 family. SIMILARITY: Contains 6 HEAT repeats. SEQUENCE CAUTION: Sequence=AAB03813.1; Type=Miscellaneous discrepancy; Note=Unknown C-terminal region; Sequence=BAB15145.1; Type=Erroneous initiation; GENE SYNONYMS: TAX1BP2 TRX. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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