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Deubiquitinating protein VCIP135
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VCIP1_HUMAN
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3.4.22.-, Valosin-containing protein p97/p47 complex-interacting protein 1, Valosin-containing protein p97/p47 complex-interacting protein p135
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FUNCTION: Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). SUBUNIT: Binds VCP and the ternary complex containing STX5A, NSFL1C and VCP (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Note=Associated with Golgi stacks and endoplasmic reticulum (By similarity). SIMILARITY: Contains 1 OTU domain. SEQUENCE CAUTION: Sequence=BAB15552.1; Type=Frameshift; Positions=1065, 1110; Sequence=BAB47479.1; Type=Erroneous initiation; GENE SYNONYMS: KIAA1850 VCIP135. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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