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http://www.biopax.org/relea...
http://www.biopax.org/relea...
Tripartite motif-containing protein 55
http://www.biopax.org/relea...
TRI55_HUMAN
http://www.biopax.org/relea...
http://www.biopax.org/relea...
MuRF-2, MuRF2, Muscle-specific RING finger protein 2, RING finger protein 29
http://www.biopax.org/relea...
FUNCTION: May regulate gene expression and protein turnover in muscle cells (By similarity). SUBUNIT: Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=p60; IsoId=Q9BYV6-1; Sequence=Displayed; Name=2; Synonyms=p50; IsoId=Q9BYV6-2; Sequence=VSP_015997; Name=3; Synonyms=p60B; IsoId=Q9BYV6-3; Sequence=VSP_015998; Name=4; Synonyms=p27; IsoId=Q9BYV6-4; Sequence=VSP_015996; TISSUE SPECIFICITY: Highly expressed in muscle. Low-level expression in liver. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 COS domain. SIMILARITY: Contains 1 RING-type zinc finger. CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator. SEQUENCE CAUTION: Sequence=AAP35876.1; Type=Erroneous initiation; Sequence=CAC32839.1; Type=Erroneous initiation; Sequence=CAC32840.1; Type=Erroneous initiation; GENE SYNONYMS: MURF2 RNF29. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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