| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-312308,
cpath:CPATH-LOCAL-312309,
cpath:CPATH-LOCAL-312310,
cpath:CPATH-LOCAL-312311,
cpath:CPATH-LOCAL-312312,
cpath:CPATH-LOCAL-312313,
cpath:CPATH-LOCAL-312314,
cpath:CPATH-LOCAL-312315,
cpath:CPATH-LOCAL-312316,
cpath:CPATH-LOCAL-312317,
cpath:CPATH-LOCAL-312318,
cpath:CPATH-LOCAL-321620
|
| http://www.biopax.org/relea... |
Urokinase-type plasminogen activator
|
| http://www.biopax.org/relea... |
UROK_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.21.73,
U-plasminogen activator,
Urokinase-type plasminogen activator chain B,
Urokinase-type plasminogen activator long chain A,
Urokinase-type plasminogen activator short chain A,
uPA
|
| http://www.biopax.org/relea... |
FUNCTION: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. CATALYTIC ACTIVITY: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin. SUBUNIT: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P00749-1; Sequence=Displayed; Name=2; IsoId=P00749-2; Sequence=VSP_038368; TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers. PTM: Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding. PHARMACEUTICAL: Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiates fibrinolysis. Clinically used for therapy of thrombolytic disorders. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 kringle domain. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=Wikipedia; Note=Urokinase entry; URL="http://en.wikipedia.org/wiki/Urokinase"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/plau/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch |