CPATH-74284

Source:http://cbio.mskcc.org/cpath#CPATH-74284

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Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	http://www.biopax.org/release/biopax-level2.owl#protein
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-307367, cpath:CPATH-LOCAL-307368, cpath:CPATH-LOCAL-307369, cpath:CPATH-LOCAL-307370, cpath:CPATH-LOCAL-307371, cpath:CPATH-LOCAL-307372, cpath:CPATH-LOCAL-307373, cpath:CPATH-LOCAL-307374, cpath:CPATH-LOCAL-307375, cpath:CPATH-LOCAL-311637
http://www.biopax.org/relea...	Homeobox protein DLX-5
http://www.biopax.org/relea...	DLX5_MOUSE
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-307365
http://www.biopax.org/relea...	FUNCTION: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. SUBUNIT: Interacts with XRCC6 (Ku70) (By similarity). SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha; IsoId=P70396-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=P70396-2; Sequence=VSP_002239; Name=3; Synonyms=Gamma; IsoId=P70396-3; Sequence=VSP_002237, VSP_002238; TISSUE SPECIFICITY: Expressed in osteoblasts and chondrocytes. DEVELOPMENTAL STAGE: Expressed in the otic vesicle, mandibular arch, branchial arches 2 and 3, in proximal anterior mesodermal domain in the limb, immature and proliferating chondroblasts at 14.5 dpc. INDUCTION: Up-regulated by BMP2. PTM: Phosphorylated. Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity. Phosphorylation by CaMK2 increases its protein stability. SIMILARITY: Belongs to the distal-less homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
skos:exactMatch	uniprot-protein:P70396
skos:closeMatch	entrez-gene:13395