| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Chromobox protein homolog 1
|
| http://www.biopax.org/relea... |
CBX1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
HP1 beta,
HP1Hsbeta,
Heterochromatin protein 1 homolog beta,
Heterochromatin protein p25,
M31,
Modifier 1 protein,
p25beta
|
| http://www.biopax.org/relea... |
FUNCTION: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. SUBUNIT: Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6. Interacts with POGZ. SUBCELLULAR LOCATION: Nucleus. Note=Unassociated with chromosomes during mitosis. TISSUE SPECIFICITY: Expressed in all adult and embryonic tissues. PTM: Not phosphorylated. PTM: Ubiquitinated. SIMILARITY: Contains 2 chromo domains. WEB RESOURCE: Name=Wikipedia; Note=Heterochromatin protein 1 entry; URL="http://en.wikipedia.org/wiki/Heterochromatin_Protein_1"; GENE SYNONYMS: CBX. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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