| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Transcriptional activator Myb
|
| http://www.biopax.org/relea... |
MYB_MOUSE
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Proto-oncogene c-Myb
|
| http://www.biopax.org/relea... |
FUNCTION: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. SUBUNIT: Binds to HIPK1 (By similarity). Interacts with HIPK2, MAF, MYBBP1A and NLK. SUBCELLULAR LOCATION: Nucleus. DOMAIN: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C- terminal domain involved in transcriptional repression. DOMAIN: C-terminal truncated mutants display increased transactivation. PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (By similarity). PTM: Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. PTM: Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels (By similarity). SIMILARITY: Contains 3 HTH myb-type DNA-binding domains. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |