| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cyclin-A2
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| http://www.biopax.org/relea... |
CCNA2_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cyclin-A
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| http://www.biopax.org/relea... |
FUNCTION: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. SUBUNIT: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. In the testis, interacts only with CDK2. When associated with CDK2 (but not with CDK1), interacts with SCAPER (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER (By similarity). TISSUE SPECIFICITY: Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells. DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis. Expressed in spermatogonia and is most abundant in preleptotene spermatocytes, cells which will enter the meiotic pathway. PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily. GENE SYNONYMS: Ccna Cyca. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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