| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cyclin-dependent kinase 2
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| http://www.biopax.org/relea... |
CDK2_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.22,
Cell division protein kinase 2
|
| http://www.biopax.org/relea... |
FUNCTION: Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2 (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it (By similarity). SUBUNIT: Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1 (By similarity). Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=CDK2-beta; IsoId=P97377-1; Sequence=Displayed; Name=CDK2-alpha; IsoId=P97377-2; Sequence=VSP_004800; SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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