Linked Life Data

CPATH-66

Source:http://cbio.mskcc.org/cpath#CPATH-66

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-66http://www.biopax.org/relea...Centromere protein Slld:biogrid
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cpath:CPATH-66http://www.biopax.org/relea...FANCM-interacting histone fold protein 1lld:biogrid
cpath:CPATH-66http://www.biopax.org/relea...Fanconi anemia-associated polypeptide of 16 kDalld:biogrid
cpath:CPATH-66http://www.biopax.org/relea...Apoptosis-inducing TAF9-like domain-containing protein 1lld:biogrid
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cpath:CPATH-66http://www.biopax.org/relea...FUNCTION: DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recorery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. As a component of the APITD1/CENPS complex, is also essential for the stable assembly of the outer kinetchore. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. SUBUNIT: Component of a discrete APITD1/CENPS complex composed of at least APITD1/CENPS and STRA13/CENPX. Belongs to the multisubunit FA complex composed of APITD1/CENPS, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and STRA13/CENPX. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and APITD1/CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts with APITD1/CENPS, FANCM and FAAP24. Binds DNA. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N2Z9-1; Sequence=Displayed; Name=2; IsoId=Q8N2Z9-2; Sequence=VSP_020434; Note=No experimental confirmation available; Name=3; IsoId=Q8N2Z9-3; Sequence=VSP_020432, VSP_020433; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the TAF9 family. GENE SYNONYMS: CENPS FAAP16 MHF1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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