Linked Life Data

CPATH-66601

Source:http://cbio.mskcc.org/cpath#CPATH-66601

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-66601http://www.biopax.org/relea...Polyhomeotic-like protein 1lld:biogrid
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cpath:CPATH-66601http://www.biopax.org/relea...Early development regulatory protein 1lld:biogrid
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cpath:CPATH-66601http://www.biopax.org/relea...mPH1lld:biogrid
cpath:CPATH-66601http://www.biopax.org/relea...FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. SUBUNIT: Homodimer. Component of a PRC1-like complex (By similarity). Interacts with the SAM domain of SCMH1 via its SAM domain in vitro. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q64028-1; Sequence=Displayed; Name=2; IsoId=Q64028-2; Sequence=VSP_004040; Name=3; IsoId=Q64028-3; Sequence=VSP_004041; Name=4; IsoId=Q64028-4; Sequence=VSP_004038, VSP_004039; TISSUE SPECIFICITY: Highly expressed in testis with lower levels in most other tissues. DEVELOPMENTAL STAGE: Expressed ubiquitously in 8.5 dpc embryos. At 10.5 dpc, strongly expressed in pharyngeal arches and weakly expressed in heart. By 14.5 dpc, expression is detected throughout the central nervous system. INDUCTION: By retinoic acid. SIMILARITY: Contains 1 FCS-type zinc finger. SIMILARITY: Contains 1 SAM (sterile alpha motif) domain. GENE SYNONYMS: Edr Edr1 Rae28. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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