Linked Life Data

CPATH-65241

Source:http://cbio.mskcc.org/cpath#CPATH-65241

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-65241http://www.biopax.org/relea...Sterol regulatory element-binding protein 1lld:biogrid
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cpath:CPATH-65241http://www.biopax.org/relea...Processed sterol regulatory element-binding protein 1lld:biogrid
cpath:CPATH-65241http://www.biopax.org/relea...SREBP-1lld:biogrid
cpath:CPATH-65241http://www.biopax.org/relea...Sterol regulatory element-binding transcription factor 1lld:biogrid
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cpath:CPATH-65241http://www.biopax.org/relea...Class D basic helix-loop-helix protein 1lld:biogrid
cpath:CPATH-65241http://www.biopax.org/relea...FUNCTION: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). SUBUNIT: Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. SUBCELLULAR LOCATION: Processed sterol regulatory element-binding protein 1: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist; Name=SREBP-1A; IsoId=P36956-1; Sequence=Displayed; Name=SREBP-1B; IsoId=P36956-2; Sequence=VSP_002150; Name=SREBP-1C; IsoId=P36956-3; Sequence=VSP_002149, VSP_002150; Name=4; IsoId=P36956-4; Sequence=VSP_030859; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. PTM: At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7. SIMILARITY: Belongs to the SREBP family. SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. SEQUENCE CAUTION: Sequence=AAB28522.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD92846.1; Type=Miscellaneous discrepancy; Note=Intron retention; WEB RESOURCE: Name=Wikipedia; Note=Sterol regulatory element- binding protein entry; URL="http://en.wikipedia.org/wiki/Sterol_regulatory_element_binding_protein"; GENE SYNONYMS: BHLHD1 SREBP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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