| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cyclin-dependent kinase 12
|
| http://www.biopax.org/relea... |
CDK12_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.22,
2.7.11.23,
CDC2-related protein kinase 7,
Cdc2-related kinase, arginine/serine-rich,
Cell division cycle 2-related protein kinase 7,
Cell division protein kinase 12,
CrkRS,
hCDK12
|
| http://www.biopax.org/relea... |
FUNCTION: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors. CATALYTIC ACTIVITY: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with CCNL1 and CCNL2 (By similarity). SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9NYV4-1; Sequence=Displayed; Name=2; IsoId=Q9NYV4-2; Sequence=VSP_030284; Name=3; IsoId=Q9NYV4-3; Sequence=VSP_040908, VSP_040909, VSP_040910; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitously expressed. DISEASE: Note=Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAA74927.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS: CRK7 CRKRS KIAA0904. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |