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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Spermidine synthase
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| http://www.biopax.org/relea... |
SPEE_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.5.1.16,
Putrescine aminopropyltransferase,
SPDSY
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| http://www.biopax.org/relea... |
FUNCTION: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. CATALYTIC ACTIVITY: S-adenosylmethioninamine + putrescine = 5'-S- methyl-5'-thioadenosine + spermidine. ENZYME REGULATION: The activity is thought to be regulated mainly by the availability of decarboxylated S-adenosylmethionine. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=20 uM for putrescine; KM=0.9 uM for S-adenosylmethioninamine; PATHWAY: Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. SUBUNIT: Homodimer or homotetramer. SIMILARITY: Belongs to the spermidine/spermine synthase family. GENE SYNONYMS: SPS1 SRML1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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