| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Suppressor of tumorigenicity 14 protein
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| http://www.biopax.org/relea... |
ST14_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.21.109,
MT-SP1,
Matriptase,
Membrane-type serine protease 1,
Prostamin,
Serine protease 14,
Serine protease TADG-15,
Tumor-associated differentially-expressed gene 15 protein
|
| http://www.biopax.org/relea... |
FUNCTION: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. CATALYTIC ACTIVITY: Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position. SUBUNIT: Interacts with CDCP1. May interact with TMEFF1. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Probable). DISEASE: Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 2 CUB domains. SIMILARITY: Contains 4 LDL-receptor class A domains. SIMILARITY: Contains 1 peptidase S1 domain. GENE SYNONYMS: PRSS14 SNC19 TADG15. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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