| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-261131,
cpath:CPATH-LOCAL-261131,
cpath:CPATH-LOCAL-261132,
cpath:CPATH-LOCAL-261132,
cpath:CPATH-LOCAL-261133,
cpath:CPATH-LOCAL-261133,
cpath:CPATH-LOCAL-261134,
cpath:CPATH-LOCAL-261134,
cpath:CPATH-LOCAL-261135,
cpath:CPATH-LOCAL-261135,
cpath:CPATH-LOCAL-261136,
cpath:CPATH-LOCAL-261136,
cpath:CPATH-LOCAL-261137,
cpath:CPATH-LOCAL-261137,
cpath:CPATH-LOCAL-261138,
cpath:CPATH-LOCAL-261138,
cpath:CPATH-LOCAL-261139,
cpath:CPATH-LOCAL-261139,
cpath:CPATH-LOCAL-261140,
cpath:CPATH-LOCAL-261140,
cpath:CPATH-LOCAL-270077,
cpath:CPATH-LOCAL-270077
|
| http://www.biopax.org/relea... |
Syntaxin-1A,
Syntaxin-1A
|
| http://www.biopax.org/relea... |
STX1A_HUMAN,
STX1A_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Neuron-specific antigen HPC-1,
Neuron-specific antigen HPC-1
|
| http://www.biopax.org/relea... |
FUNCTION: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25. Interacts with OTOF and LGI3. Interacts with SLC6A4. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16623-1; Sequence=Displayed; Name=2; Synonyms=1C; IsoId=Q16623-2; Sequence=VSP_006338; Name=3; IsoId=Q16623-3; Sequence=VSP_006339; TISSUE SPECIFICITY: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. DISEASE: Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. SIMILARITY: Belongs to the syntaxin family. SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain. SEQUENCE CAUTION: Sequence=AAA20940.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS: STX1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25. Interacts with OTOF and LGI3. Interacts with SLC6A4. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU. SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein (By similarity). Cell junction, synapse, synaptosome (By similarity). SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16623-1; Sequence=Displayed; Name=2; Synonyms=1C; IsoId=Q16623-2; Sequence=VSP_006338; Name=3; IsoId=Q16623-3; Sequence=VSP_006339; TISSUE SPECIFICITY: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. DISEASE: Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. SIMILARITY: Belongs to the syntaxin family. SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain. SEQUENCE CAUTION: Sequence=AAA20940.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS: STX1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |