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| http://www.biopax.org/relea... | |
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Structural maintenance of chromosomes protein 3
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| http://www.biopax.org/relea... |
SMC3_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Bamacan,
Basement membrane-associated chondroitin proteoglycan,
Chondroitin sulfate proteoglycan 6,
Chromosome segregation protein SmcD,
Mad member-interacting protein 1,
SMC protein 3,
SMC-3
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| http://www.biopax.org/relea... |
FUNCTION: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. SUBUNIT: Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and a function in chromosome movement. Interacts with SYCP2. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/APRIN and PDS5B/SCC-112. Interacts with PDS5A and WAPAL; regulated by SMC3 acetylation (By similarity). Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Interacts with MXI1, MXD3 and MXD4. SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. TISSUE SPECIFICITY: Widely expressed, with higher expression in testis and brain. DOMAIN: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication (By similarity). SIMILARITY: Belongs to the SMC family. SMC3 subfamily. CAUTION: Was originally isolated as a proteoglycan protein (explaining its name). Although not excluded, such secreted function is not clear. SEQUENCE CAUTION: Sequence=CAA75400.1; Type=Frameshift; Positions=522, 1018, 1144; GENE SYNONYMS: Bam Bmh Cspg6 Mmip1 Smc3l1 Smcd. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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