| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Dual specificity protein phosphatase CDC14B
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| http://www.biopax.org/relea... |
CC14B_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.1.3.16,
3.1.3.48,
CDC14 cell division cycle 14 homolog B
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| http://www.biopax.org/relea... |
FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. SUBUNIT: Interacts with FZR1/CDH1. SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=2; Synonyms=CDC14B2; IsoId=O60729-1; Sequence=Displayed; Name=1; Synonyms=CDC14B1; IsoId=O60729-2; Sequence=VSP_012038; Name=3; Synonyms=CDC14B3; IsoId=O60729-3; Sequence=VSP_012039; Name=4; IsoId=O60729-4; Sequence=VSP_030720; DOMAIN: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. SEQUENCE CAUTION: Sequence=CAI40539.1; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc14b/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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