| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-2757,
cpath:CPATH-LOCAL-2757,
cpath:CPATH-LOCAL-2758,
cpath:CPATH-LOCAL-2758,
cpath:CPATH-LOCAL-2759,
cpath:CPATH-LOCAL-2759,
cpath:CPATH-LOCAL-2760,
cpath:CPATH-LOCAL-2760,
cpath:CPATH-LOCAL-2761,
cpath:CPATH-LOCAL-2761,
cpath:CPATH-LOCAL-2762,
cpath:CPATH-LOCAL-2762,
cpath:CPATH-LOCAL-2763,
cpath:CPATH-LOCAL-2763,
cpath:CPATH-LOCAL-2764,
cpath:CPATH-LOCAL-2764,
cpath:CPATH-LOCAL-2765,
cpath:CPATH-LOCAL-2765,
cpath:CPATH-LOCAL-9433,
cpath:CPATH-LOCAL-9433
|
| http://www.biopax.org/relea... |
G1/S-specific cyclin-E1,
G1/S-specific cyclin-E1
|
| http://www.biopax.org/relea... |
CCNE1_HUMAN,
CCNE1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
FUNCTION: Essential for the control of the cell cycle at the G1/S (start) transition. SUBUNIT: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=E1L; Synonyms=E-L; IsoId=P24864-1; Sequence=Displayed; Name=E1S; IsoId=P24864-2; Sequence=VSP_001253; Note=Lacks 49 residues within the cyclin box and cannot complex with CDK2; Name=3; Synonyms=E-S; IsoId=P24864-3; Sequence=VSP_037381; TISSUE SPECIFICITY: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. PTM: Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the cyclin family. Cyclin E subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne1/"; GENE SYNONYMS: CCNE. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Essential for the control of the cell cycle at the G1/S (start) transition. SUBUNIT: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=E1L; Synonyms=E-L; IsoId=P24864-1; Sequence=Displayed; Name=E1S; IsoId=P24864-2; Sequence=VSP_001253; Note=Lacks 49 residues within the cyclin box and cannot complex with CDK2; Name=3; Synonyms=E-S; IsoId=P24864-3; Sequence=VSP_037381; TISSUE SPECIFICITY: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. PTM: Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the cyclin family. Cyclin E subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne1/"; GENE SYNONYMS: CCNE. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |