Linked Life Data

CPATH-58

Source:http://cbio.mskcc.org/cpath#CPATH-58

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-58http://www.biopax.org/relea...T-cell surface glycoprotein CD3 zeta chainlld:biogrid
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cpath:CPATH-58http://www.biopax.org/relea...CD247lld:biogrid
cpath:CPATH-58http://www.biopax.org/relea...T-cell receptor T3 zeta chainlld:biogrid
cpath:CPATH-58http://www.biopax.org/relea...FUNCTION: Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1; this interaction up- regulates the expression of the Fas ligand (FASLG) at the cell surface. Interacts with HIV-2 Nef protein; this interaction induces down-regulation of cell surface TCR/CD3 complexes. Interacts with SHB. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CD-3-zeta; IsoId=P20963-1; Sequence=Displayed; Name=2; Synonyms=CD-3-eta; IsoId=P20963-2; Sequence=Not described; Name=3; IsoId=P20963-3; Sequence=VSP_036459; DOMAIN: The ITAM domains mediate interaction with SHB. PTM: Phosphorylated on Tyr residues after T-cell receptor triggering (By similarity). DISEASE: Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. SIMILARITY: Belongs to the CD3Z/FCER1G family. SIMILARITY: Contains 3 ITAM domains. WEB RESOURCE: Name=CD247base; Note=CD247 mutation db; URL="http://bioinf.uta.fi/CD247base/"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cd3z/"; GENE SYNONYMS: CD3Z T3Z TCRZ. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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