| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Phosphoglycerate kinase 1
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| http://www.biopax.org/relea... |
PGK1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.2.3,
Cell migration-inducing gene 10 protein,
PRP 2,
Primer recognition protein 2
|
| http://www.biopax.org/relea... |
FUNCTION: In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). CATALYTIC ACTIVITY: ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate. PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 2/5. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE: Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:300653]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations. SIMILARITY: Belongs to the phosphoglycerate kinase family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PGK1"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PGK1"; WEB RESOURCE: Name=Wikipedia; Note=Phosphoglycerate kinase entry; URL="http://en.wikipedia.org/wiki/Phosphoglycerate_kinase"; GENE SYNONYMS: PGKA. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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