| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-234657,
cpath:CPATH-LOCAL-234657,
cpath:CPATH-LOCAL-234658,
cpath:CPATH-LOCAL-234658,
cpath:CPATH-LOCAL-234659,
cpath:CPATH-LOCAL-234659,
cpath:CPATH-LOCAL-234660,
cpath:CPATH-LOCAL-234660,
cpath:CPATH-LOCAL-234661,
cpath:CPATH-LOCAL-234661,
cpath:CPATH-LOCAL-241971,
cpath:CPATH-LOCAL-241971
|
| http://www.biopax.org/relea... |
E3 SUMO-protein ligase PIAS3,
E3 SUMO-protein ligase PIAS3
|
| http://www.biopax.org/relea... |
PIAS3_HUMAN,
PIAS3_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Protein inhibitor of activated STAT protein 3,
Protein inhibitor of activated STAT protein 3
|
| http://www.biopax.org/relea... |
FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. PATHWAY: Protein modification; protein sumoylation. SUBUNIT: Binds SUMO1 and UBE2I. Interacts with AR, BCL11A, GFI1, HMGA2, IRF1, MITF, NCOA2, as well as with STAT3, after treatment with IL6, CNTF or OSM and with STAT5, after PRL stimulation (By similarity). Interacts with PLAG1. Interacts with ZFHX3. SUBCELLULAR LOCATION: Nucleus speckle (By similarity). TISSUE SPECIFICITY: Widely expressed. INDUCTION: By dihydrotestosterone (DHT) in prostate cancer cells. DOMAIN: The LXXLL motif is a transcriptional coregulator signature. PTM: Sumoylated (By similarity). SIMILARITY: Belongs to the PIAS family. SIMILARITY: Contains 1 PINIT domain. SIMILARITY: Contains 1 SAP domain. SIMILARITY: Contains 1 SP-RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAA78533.1; Type=Erroneous initiation; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. PATHWAY: Protein modification; protein sumoylation. SUBUNIT: Binds SUMO1 and UBE2I. Interacts with AR, BCL11A, GFI1, HMGA2, IRF1, MITF, NCOA2, as well as with STAT3, after treatment with IL6, CNTF or OSM and with STAT5, after PRL stimulation (By similarity). Interacts with PLAG1. Interacts with ZFHX3. SUBCELLULAR LOCATION: Nucleus speckle (By similarity). TISSUE SPECIFICITY: Widely expressed. INDUCTION: By dihydrotestosterone (DHT) in prostate cancer cells. DOMAIN: The LXXLL motif is a transcriptional coregulator signature. PTM: Sumoylated (By similarity). SIMILARITY: Belongs to the PIAS family. SIMILARITY: Contains 1 PINIT domain. SIMILARITY: Contains 1 SAP domain. SIMILARITY: Contains 1 SP-RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAA78533.1; Type=Erroneous initiation; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |