| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Prostatic acid phosphatase
|
| http://www.biopax.org/relea... |
PPAP_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.1.3.2,
3.1.3.5,
5'-NT,
5'-nucleotidase,
Ecto-5'-nucleotidase,
PAPf39,
TMPase,
Thiamine monophosphatase
|
| http://www.biopax.org/relea... |
FUNCTION: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. FUNCTION: Isoform 2: the cellular form also has ecto-5'- nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol + phosphate. CATALYTIC ACTIVITY: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. ENZYME REGULATION: Phosphatase activity inhibited by L(+)- tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid. SUBUNIT: Homodimer; dimer formation is required for phosphatase activity (By similarity). SUBCELLULAR LOCATION: Isoform 1: Secreted. SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Secreted PAP, sPAP; IsoId=P15309-1; Sequence=Displayed; Name=2; Synonyms=TMPase, TM-PAP, cellular PAP, cPAP; IsoId=P15309-2; Sequence=VSP_036023; TISSUE SPECIFICITY: Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer. PTM: N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides. PTM: Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta- sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection. MISCELLANEOUS: Used as a diagnostic tool for staging metastatic prostatic cancer. SIMILARITY: Belongs to the histidine acid phosphatase family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |