| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Bone marrow proteoglycan
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| http://www.biopax.org/relea... |
PRG2_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
BMPG,
EMBP,
Eosinophil granule major basic protein,
MBP,
Pregnancy-associated major basic protein,
Proteoglycan 2
|
| http://www.biopax.org/relea... |
FUNCTION: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. SUBUNIT: In pregnancy serum, the proform exists as a disulfide- linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg. SUBCELLULAR LOCATION: Bone marrow proteoglycan: Secreted. Note=The proform is secreted. SUBCELLULAR LOCATION: Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). TISSUE SPECIFICITY: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. DEVELOPMENTAL STAGE: Levels of the proform increase in serum and placenta during pregnancy. PTM: Nitrated. MISCELLANEOUS: Binds heparin. Does not bind calcium. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Wikipedia; Note=Major basic protein entry; URL="http://en.wikipedia.org/wiki/Major_basic_protein"; WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Eosinophil major basic protein; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_207"; GENE SYNONYMS: MBP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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