| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-2602,
cpath:CPATH-LOCAL-2602,
cpath:CPATH-LOCAL-2603,
cpath:CPATH-LOCAL-2603,
cpath:CPATH-LOCAL-2604,
cpath:CPATH-LOCAL-2604,
cpath:CPATH-LOCAL-2605,
cpath:CPATH-LOCAL-2605,
cpath:CPATH-LOCAL-2606,
cpath:CPATH-LOCAL-2606,
cpath:CPATH-LOCAL-2607,
cpath:CPATH-LOCAL-2607,
cpath:CPATH-LOCAL-2608,
cpath:CPATH-LOCAL-2608,
cpath:CPATH-LOCAL-2609,
cpath:CPATH-LOCAL-2609,
cpath:CPATH-LOCAL-2610,
cpath:CPATH-LOCAL-2610,
cpath:CPATH-LOCAL-2611,
cpath:CPATH-LOCAL-2611,
cpath:CPATH-LOCAL-2612,
cpath:CPATH-LOCAL-2612,
cpath:CPATH-LOCAL-2613,
cpath:CPATH-LOCAL-2613,
cpath:CPATH-LOCAL-2614,
cpath:CPATH-LOCAL-2614,
cpath:CPATH-LOCAL-2615,
cpath:CPATH-LOCAL-2615,
cpath:CPATH-LOCAL-9417,
cpath:CPATH-LOCAL-9417
|
| http://www.biopax.org/relea... |
Caspase-2,
Caspase-2
|
| http://www.biopax.org/relea... |
CASP2_HUMAN,
CASP2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.22.55,
3.4.22.55,
CASP-2,
CASP-2,
Caspase-2 subunit p12,
Caspase-2 subunit p12,
Caspase-2 subunit p13,
Caspase-2 subunit p13,
Caspase-2 subunit p18,
Caspase-2 subunit p18,
NEDD-2,
NEDD-2,
Neural precursor cell expressed developmentally down-regulated protein 2,
Neural precursor cell expressed developmentally down-regulated protein 2,
Protease ICH-1,
Protease ICH-1
|
| http://www.biopax.org/relea... |
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. CATALYTIC ACTIVITY: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-. SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Comment=Isoforms differ in the N- and C-termini; Name=1; Synonyms=ICH-1L; IsoId=P42575-1; Sequence=Displayed; Note=Acts as a positive regulator of apoptosis; Name=2; Synonyms=ICH-1S; IsoId=P42575-2; Sequence=VSP_000801, VSP_000802; Note=Acts as a negative regulator of apoptosis; TISSUE SPECIFICITY: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. PTM: The mature protease can process its own propeptide, but not that of other caspases. SIMILARITY: Belongs to the peptidase C14A family. SIMILARITY: Contains 1 CARD domain. SEQUENCE CAUTION: Sequence=AAA58959.1; Type=Erroneous initiation; Sequence=AAO25653.1; Type=Erroneous initiation; Sequence=AAP22346.1; Type=Erroneous initiation; Sequence=AAP22349.1; Type=Erroneous initiation; Sequence=BAD92877.1; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp2/"; GENE SYNONYMS: ICH1 NEDD2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. CATALYTIC ACTIVITY: Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-. SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Comment=Isoforms differ in the N- and C-termini; Name=1; Synonyms=ICH-1L; IsoId=P42575-1; Sequence=Displayed; Note=Acts as a positive regulator of apoptosis; Name=2; Synonyms=ICH-1S; IsoId=P42575-2; Sequence=VSP_000801, VSP_000802; Note=Acts as a negative regulator of apoptosis; TISSUE SPECIFICITY: Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. PTM: The mature protease can process its own propeptide, but not that of other caspases. SIMILARITY: Belongs to the peptidase C14A family. SIMILARITY: Contains 1 CARD domain. SEQUENCE CAUTION: Sequence=AAA58959.1; Type=Erroneous initiation; Sequence=AAO25653.1; Type=Erroneous initiation; Sequence=AAP22346.1; Type=Erroneous initiation; Sequence=AAP22349.1; Type=Erroneous initiation; Sequence=BAD92877.1; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp2/"; GENE SYNONYMS: ICH1 NEDD2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch |