| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-24417,
cpath:CPATH-LOCAL-24417,
cpath:CPATH-LOCAL-24418,
cpath:CPATH-LOCAL-24418,
cpath:CPATH-LOCAL-24419,
cpath:CPATH-LOCAL-24419,
cpath:CPATH-LOCAL-24420,
cpath:CPATH-LOCAL-24420,
cpath:CPATH-LOCAL-24421,
cpath:CPATH-LOCAL-24421,
cpath:CPATH-LOCAL-24422,
cpath:CPATH-LOCAL-24422,
cpath:CPATH-LOCAL-24423,
cpath:CPATH-LOCAL-24423,
cpath:CPATH-LOCAL-24424,
cpath:CPATH-LOCAL-24424,
cpath:CPATH-LOCAL-27292,
cpath:CPATH-LOCAL-27292
|
| http://www.biopax.org/relea... |
Keratin, type I cytoskeletal 18,
Keratin, type I cytoskeletal 18
|
| http://www.biopax.org/relea... |
K1C18_HUMAN,
K1C18_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CK-18,
CK-18,
Cell proliferation-inducing gene 46 protein,
Cell proliferation-inducing gene 46 protein,
Cytokeratin-18,
Cytokeratin-18,
K18,
K18,
Keratin-18,
Keratin-18
|
| http://www.biopax.org/relea... |
FUNCTION: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. SUBUNIT: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin- antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. TISSUE SPECIFICITY: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. INDUCTION: By IL6/interleukin-6. PTM: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. PTM: Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. PTM: O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. DISEASE: Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600]. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). SIMILARITY: Belongs to the intermediate filament family. WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; URL="http://www.interfil.org"; GENE SYNONYMS: CYK18. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. SUBUNIT: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin- antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. TISSUE SPECIFICITY: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. INDUCTION: By IL6/interleukin-6. PTM: Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. PTM: Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. PTM: O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. DISEASE: Defects in KRT18 are a cause of cirrhosis (CIRRH) [MIM:215600]. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). SIMILARITY: Belongs to the intermediate filament family. WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; URL="http://www.interfil.org"; GENE SYNONYMS: CYK18. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |