| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Centrosomal protein of 72 kDa
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| http://www.biopax.org/relea... |
CEP72_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cep72
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| http://www.biopax.org/relea... |
FUNCTION: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). SUBUNIT: Interacts with KIZ/PLK1S1. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9P209-1; Sequence=Displayed; Name=2; IsoId=Q9P209-2; Sequence=VSP_037835, VSP_037836; Note=No experimental confirmation available; SIMILARITY: Belongs to the CEP72 family. SIMILARITY: Contains 3 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SEQUENCE CAUTION: Sequence=BAA91685.1; Type=Erroneous initiation; Sequence=BAA96043.1; Type=Erroneous initiation; GENE SYNONYMS: KIAA1519. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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