| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Du-CYLD-TRAF2
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
PHYSIOL-LEFT-TO-RIGHT
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Deubiquitination of TRAF2 by CYLD.1) CYLD has deubiquitinating activity that negatively modulates TRAF-mediated activation of IKK, indicating that ubiquitination is involved in IKK activation by TRAFs.2) CYLD negatively regulates TRAF-dependent NF-B activation.3) An evolutionarily conserved motif located at the C terminus of known CYLD orthologues from various species corresponds to subdomain III of the UBP histidine box domain is involved in the deubiquitinase activity.
|